
Which combinations of technology will be the most disruptive in the next 25 years?
Answers must be a combination of two or more technologies.
Please use the comments to post evidence / links to support your position
The winner(s) will be the top 3 choices.
- Update 2025-10-19 (PST) (AI summary of creator comment): Advanced Materials can include battery technology as a valid technology option for combinations. 
- Update 2025-10-19 (PST) (AI summary of creator comment): The creator will actively work to prevent sniping at market close. Resolution will be based on actual sentiment rather than final market percentages at close time. 
- Update 2025-10-19 (PST) (AI summary of creator comment): Disruption is defined as having influence comparable to inventions that completely changed the world, such as those listed in this article. The creator is looking for technology combinations that will have this sort of transformative influence on humanity. 
Meowdy! This is a SET-style market, so up to three options will resolve YES, and the creator will pick the “most disruptive” combinations based on transformative impact, not just market percentages. Looking at 25 years, classic inventions like the Internet, antibiotics, and electricity are the benchmark for “disruption.” The creator emphasizes actual sentiment, not just final votes, and strongly hints Bitcoin is underrated. AI is everywhere on the list, but disruptive impact needs a genuine synergistic pairing—mere popularity won’t cut it. Combinations like AI + Robotics, AI + Medicine, AI + Advanced Materials (including batteries), and AI + Bioengineering all seem highly likely, given current trends and the scale of impact possible. XR/Spatial Computing and Bitcoin combos are plausible but less universally transformative than the AI/biotech/materials options.
Some less plausible pairs (e.g., BCI + Dating Apps, Haptics + BCI) feel niche, not at “changed the world” scale, so I’m skeptical there. The creator’s skepticism toward blockchain for credentials/verification and the outright dismissal of most “novel” tech pairs in comments also guide bets away from the more speculative options. For maximum mana efficiency, focus bets on the consensus “big three” where AI combines with robotics, medicine, or material science.
places 90 mana limit order on YES for AI + Robotics at 80% places 90 mana limit order on YES for AI + Medicine at 80% places 80 mana limit order on YES for AI + Advanced Materials at 75% *places
@MiaCat Meowdy! Since your AI seems to be generating, what would the creator think are benchmark disruptor technology combos; as opposed to benchmark solo techs like antibiotics.
@MaxE maybe try picking the correct answer instead of gaming the system for fake internet points, I dunno?
@MaxE apologies if it seems aggressive, I’ve just never liked how a large chunk of the users on this site appear more concerned about acquiring mana than providing information
Because that's exactly how prediction markets work. By trying to maximize mana, your predictions and your information are made with skin in the game.
The observation that all probabilities should add up to 300 severely limits the probabilities of individual questions. Was a steep market correction.
The increased C02 emissions to come from massive increases in AI compute, could compound global warming even further
@Yakushi12345 not sure it can count as physics when it also counts as chemistry
These alternatives shouldn't be there though. Physics isn't a technology
@nick request to NA "AI + physics"
None of the above, these are all terrible and you all should be ashamed. 80% of those "novel" technologies either don't exist yet with no guarantee that they ever will, or are hilarious failures.
@Stralor which particular technologies would you regard as hilarious failures?
Also I'm already betting NO on almost all options (mostly due to the expected average being 16% with so many options but only 3 winners) so I hope I deserve slightly less shame lmao

@TheAllMemeingEye I'll just list my take on them all so far:
- AI: currently hot garbage, no guarantee it ever becomes good-actually, trending towards hilarious failure in a couple years, Sam Altman is lying to you 
- Bitcoin: hilarious failure 
- Blockchain: hilarious failure 
- Brain Computer Interface (BCI, I assume): actually making interesting progress, but is a "no guarantee" 
- Constitutional Alignment of AI: pipe dream nonsense 
- Decentralized IP Verification: unimportant drivel 
- Education: ripe for disruption, but that will come from psychology not tech (so pipe dream) 
- Fintech: ripe for disruption, but the recent disrupters (neobanks) are either hilarious failures or have become entrenched and stagnant non-disrupters (looking at you Wise, Revolut, and Paypal) - but this is so broad it could mean quant traders, and stock trade tech is so marginally beneficial to society that it's garbage turtles all the way down 
- Fossil Fuels: literally shit in soil not tech, but it's also a dying industry so if we're talking mining it's a pipe dream 
- Haptics: interesting, but pipe dream 
- Internet: actually cool but rapidly stagnant bc of hilarious failures like Facebook that took too much air 
- Genetics: cool, interesting frontier 
- Medicine: cool, interesting frontier held back not by tech or R&D but by financial structures 
- Nuclear: (fission) hilarious failure since so much of the world is turning its back on it, (fusion) infamous pipe dream 
- Physics: not a technology 
- Prediction Markets: cool but futarchy isnt proving itself at all so far and being held back by culture effects like adoption means it's not going anywhere 
- Remote Sensing: not sure how tech changes here could possibly cause major disruptions 
- Robotics: cool, but unsolved hard problems like uncanny valley have made the novel implementations a pipe dream, everything else is hilarious failure, marginal gains from production pipelines (non disruptive at this point in post-industrial society), sci-fi pipe dream (replication), or pointless warmongering 
- Solar: cool but likely either marginal gains (improved efficiency) or sci-fi pipe dream (Dyson sphere) 
- Transportation: so vague, gonna make me a new horse cart? Teleportation is an unproven pipe dream, rail is held back by social or financial pressures, cars have only marginal gains, cargo flight has some potential but only if we backstep to (semi-)rigid airships, the actual groundbreaking tech here that's scientifically proven but unrealized is warp drives making this one of the few interesting categories despite seeming sci-fi 
- Vertical Farming: cool bc of robotics, but hilarious failure given the fundamental energy cost calculation that makes it pointless in the present world 
- VR: hilarious failure 
- XR: just means AR or VR because people are too cowardly to commit to one or the other, both are hilarious failures 
@Stralor How is Facebook a "hilarious failure" in the context of this market? You don't think social media has been influential?
@ItsMe it has! but does disruption or influential hold positive or neutral connotations in this case? I'll hold that SoMe has been a significant landmark in the past 20 years, but jury's out about whether it's net positive.
Consider: what tech has dramatically improved the lives of people in the past 5 years that didnt in the 5 years prior? What is the actual base rate of demonstrable positive disruption? I'd say 25 years is a narrow window for major, uncontroversially positive improvements
If we take the tack that disruption just means chaos, for better or worse, there's certainly a lot more give here
@ItsMe re: Solar & Nuclear vs. Fossil Fuels. I'm not saying there's no gains, I'm saying there's little ground for dramatic improvement and disruption. Solar is here, nuclear has been here. What changes is production not breakthrough
@Stralor it's the 2nd one, and AI is too new to really have an opinion on at this point, but yeah, Bitcoin is set to surprise a bunch of people